Study The Effect of Some Energy Drinks on The Liver and Pancreas Functions in Male Albino Mice

Abstract

The current study aimed to determine the extent of the effects of energy drinks on the liver and pancreatic functions. The study was conducted on (35) male albino mice, whose weighting between (26-28 gm). The mice were divided into five groups (7/ group): the 1^st group, received a diet and pure water, the 2^nd group: which received an oral dose of 7.5mg\kg RB, the 3^rd group received an oral dose of 15mg\kg RB, and the 4^th group received an oral dose of 7.5 mg\kg PH and the 5^th group were orally dosed with 15mg\kg PH,  and after end of the experiment period, the mice were sacrificed and blood samples were collected for biochemical tests, liver and pancreas were extracted for histological study. The results obtained from the biochemical analysis showed that no significant differences were recorded in liver enzymes and liver tissue. While there was a significant increase p<0.05 in glucose level in the 2^nd group treated with 7mg/kg RB, and in cholesterol and HDL levels in the 4^th and 5^th groups that treated with 7.5mg/kg & 15mg/kg PH, as will as there was a significant increase p<0.05 in the insulin hormone concentration in the 3^rd group that treated with 15mg/kg RB. The results of the tissue samples showed that no changes were recorded in the liver tissues and cells, while there were cells necrosis, inflammation, fibrosis of pancreatic tissue, bacterial infection, and bacterial pancreatitis. These results indicate that energy drinks cause tissue damage.