Volume :Alq. J. Med. App. Sci. Volume 1, issue 1, 2017

Article Type :

Research Article : Screening for Analgesic and Anti-Inflammatory Effect of Antioxidants by Applying Formalin Test Using Albino Mice

Authors :
Aburawi S*, Al Tubuly R, Friwan A, Al-Ghdamsi M

Authors Affiliations :
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Libya


Abstract :

Objective: Aim of this work is to evaluate analgesic and anti-inflammatory effects of antioxidants. Methods: Formalin test was applied using albino mice. This model constitutes two distinct phases: the first phase represents the irritating effect of formalin at the sensorial fiber-C, while the second phase is inflammatory pain response. Results: Vitamin C, vitamin E and selenium have analgesic effect for neuropathic pain. Vitamin E and selenium produce anti-inflammatory effect.Conclusion: Analgesic effect for neuropathic pain was observed with vitamin C, vitamin E and selenium treatment. Anti-inflammatory effect is produced by vitamin E and selenium administration; while Vitamin C produces insignificant decrease in inflammation in the dose used.

Copyright: Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.